Rare Variants and Transcriptomics in Alzheimer disease
نویسندگان
چکیده
منابع مشابه
Rare ABCA7 variants in 2 German families with Alzheimer disease
Objective The aim of this study was to identify variants associated with familial late-onset Alzheimer disease (AD) using whole-genome sequencing. Methods Several families with an autosomal dominant inheritance pattern of AD were analyzed by whole-genome sequencing. Variants were prioritized for rare, likely pathogenic variants in genes already known to be associated with AD and confirmed by ...
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Much progress has been made in recent years in identifying genes involved in the risk of developing Alzheimer's disease (AD), the most common form of dementia. Yet despite the identification of over 20 disease associated loci, mainly through genome wide association studies (GWAS), a large proportion of the genetic component of the disorder remains unexplained. Recent evidence from the AD field,...
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ژورنال
عنوان ژورنال: Current Genetic Medicine Reports
سال: 2014
ISSN: 2167-4876
DOI: 10.1007/s40142-014-0035-9